The Centers for Medicare & Medicaid Services (CMS) has announced twenty Special Innovation Projects awarded to twelve regional Quality Innovation Network-Quality Improvement Organizations (QIN-QIOs), that focus on evidence-based efforts to improve care at lower cost and to spread local innovations for larger impact. In characterizing these awards, the American Health Quality Association—the QIO trade association—noted that special funding will be made available to address quality of life improvement for residents in nursing homes, the reduction of opioid misuse, improvement in chronic care management, and the acceleration of treatment for better stroke outcomes, among other important healthcare quality issues. AHQA noted that these projects align with the CMS Quality Strategy, which addresses improving population health, providing better care for individuals and lowering cost through improvement. “The QIN-QIOs are excited about the opportunity to implement these new initiatives, which encourage flexible and innovative approaches to improving the lives and health of Medicare beneficiaries,” according to a statement from Jane Brock, MD, MSPH, AHQA President. Projects had to be scientifically sound, with a strong analytic framework, containing interventions based on evidence, and demonstrating sound local, regional, and national partnerships. The award made to the IPRO-led Atlantic Quailty Innovation Network focuses on operationalizing the MAPPP tool, a mobile/Web-based application that supports clinical decision making regarding management of anticoagulation in the peri-procedural period. For information on all 20 awards, visit www.qioprogram.org.