As part of its Patient Safety Theme, the Centers for Medicare & Medicaid Services has contracted with Quality Improvement Organizations (QIOs) across the nation to help healthcare providers reduce Methicillin-resistant Staphylococcus aureus (MRSA) infections in their facilities. MRSA causes approximately 94,000 serious infections and 19,000 deaths in the U.S. each year. Of these, 86% are healthcare associated and 14% are community associated. The QIOs provide technical assistance and educational tools that providers can use to design MRSA interventions. Since August 2008, IPRO has been working with 60 hospitals throughout the state on MRSA-by far the largest number of participating hospitals for any state in the initiative. IPRO provides support to one unit in each of these hospitals, with the goal of achieving a 28% reduction in MRSA infection rates by the end of July 2011. IPRO staff has met with infection control leadership at each participating hospital, conducted medical record audits and examined each hospital’s infection prevention policy, in order to help design appropriate interventions. Patient and visitor education are key to this initiative, and IPRO has created educational tools that hospitals can use, such as fact sheets and posters. IPRO has also developed positive reinforcement tools for hospital staff, employee newsletter article templates, videos and other materials. IPRO’s Patient Safety page has the aforementioned tools, and more, available at: http://www.ipro.org/index/patient-safety-hospitals