Quality Innovation Network-Quality Improvement Organizations like IPRO have been given a major role in federal efforts to address the nation’s opioid epidemic. An estimated 42,000 Americans were killed by opioids in 2016 with 40% of all opioid deaths involving prescription opioids. Under comprehensive legislation passed last fall – The REACH OUT ACT of 2018 – QIN-QIOs have been tasked with identifying and working with practitioners who are opioid prescribing “high-outliers.” IPRO and partner organizations in South Carolina and the District of Columbia are already engaged in a two-year effort to support increases in naloxone prescriptions and decreases in opioid prescribing, with the goal of decreasing opioid-related visits to hospital emergency rooms. IPRO is also working with the University Of Buffalo School Of Pharmacy to deliver accredited continuing education programs to pharmacists. A new CMS fact sheet indicates that only 20% of individuals with opioid use disorder actually receive treatment. Access the CMS Roadmap to Address the Opioid Epidemic at www.cms.gov.